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MS can cause almost any neurologic symptom since it can affect any area of the brain, optic nerve, and spinal cord.
Alcohol can increase the absorption of tizanidine, possibly increasing the levels of the medication in the blood.
At endpoint (the protocol-specified time of outcome assessment), there was a statistically significant reduction in muscle tone and frequency of spasms in the Zanaflex treated group compared to placebo.
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NICE stated that long-term use of benzodiazepines for panic disorder with or without is an unlicensed indication, does not have long-term efficacy, and is, therefore, not recommended by clinical guidelines.
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In most cases, such asymptomatic signs reflect mild HIV-associated spinal cord disease that may or may not progress.
Similar alpha 2-receptor-mediated inhibition of interneuronal activity appears to underlie the additional antinociceptive and anticonvulsant activity of tizanidine reported in several species and test paradigms.
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